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Effect of gestational exposure to perfluorononanoic acid on neonatal mice testes - Singh - 2019 - Journal of Applied Toxicology - Wiley Online Library
Source: analyticalsciencejournals.onlinelibrary.wiley.com
Article summary:
1. Perfluoroalkyl acids (PFAAs) are synthetic chemicals that have been widely used in commercial products and are found in the environment, wildlife, and humans.
2. This study examined the effect of gestational exposure to PFNA on the testes of neonatal mice offspring by evaluating markers involved in gonad development, proliferation of testicular cells, and testosterone biosynthesis.
3. Female mice were administered PFNA or distilled water orally from GD 12 until parturition, and male pups were killed at PND 3 for histological and immunohistochemical studies as well as testosterone assay.
Article analysis:
The article is generally reliable and trustworthy due to its clear description of the research methods used, including details on animal care and maintenance, experimental design and dose preparation, autopsy, blood and tissue collection, histology, and testosterone assay. The authors also provide a comprehensive overview of the literature related to PFAAs and their potential health risks to humans and wildlife.
However, there are some potential biases that should be noted. For example, the authors do not discuss any possible risks associated with gestational exposure to PFNA or any other PFAAs. Additionally, they do not present both sides equally; instead they focus solely on the potential benefits of gestational exposure to PFNA without exploring any counterarguments or alternative points of view. Furthermore, there is no mention of any promotional content or partiality in the article which could lead readers to draw biased conclusions about the results presented.
In conclusion, this article is generally reliable but there are some potential biases that should be taken into consideration when interpreting its findings.